Tuesday, August 07, 2012

MTHFR Gene: The missing Fibromyalgia Link?

MTHRF genetic mutation is linked to fibromyalgia. If you have a MTHRF generatic mutation you have some degree of difficulty processing folate (a B vitamin) adequately. MTHFR is shorthand for a specific gene that codes for an enzyme called “Methyl Tetra Hydro Folate Reductase”.  Folate is very important for normal metabolism. Folic acid shortfalls can lead to fatigue, brain fog, head pain, body aches, joint pain, blue moods, migraines, and GI problems (sounds a lot like Fibro doesn't it?). To confirm a mutation, ask your doctor to order the MTHFR blood test and check glutathione levels (these tests are covered by most health insurance). Having a MTHRF genetic mutation can cause (how many of these are also symptoms of Fibro?).
  • Depression / Anxiety
  • Insomnia 
  • Fibromyalgia
  • Chronic fague
  • Immune disorders
  • Allergies
  • Autoimmune issues
  • Headaches
  • Mood issues
    A first step that will ease minor symptoms for individuals with this progblem, is eating a Mediterranean-Style Diet that includes folate-rich vegetables and fruit such as leafy greens and citrus fruit and juices.

    A second step you may want to try is supplementing with methylated folate, a form the body can process even with a faulty MTHFR gene. It is suggested that 3-7 mg a day will help ease symptoms if you already have them. One word of caution: doses at this level may initially cause you to feel worse before you feel better as the folate releases built-up toxins. If that happens, lower the dose until your body adjusts. Some sources that can be found at web sites such as iHerb are Solgar Folate Metafolin and Thorne 5-MTHF.

    I will let you know how I do with my own methylated folate supplementation as time goes by! Hope you enjoyed this fibro thought (and recipe) today!
    Black Bean Salsa
    • 1 (15 ounce) can BUSH'S® Black Beans, rinsed and drained*
    •  1 (8 ounce) can shoepeg corn, drained
    • 1 (14.5 ounce) can diced tomatoes (basil, garlic, oregano flavored)
    •  1 (10 ounce) can Ro-tel diced tomatoes 
    • 8 ounces Italian dressing 
    • 1 medium onion, chopped
    • 1 medium jalapeno, chopped
    Mix all ingredients together and refrigerate for at least 1 1/2 hours. Serve with tortilla chips.


    1. Great info - I am taking the 23andme test to figure this all out - Also - beautiful blog!!


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